Psycho-Babble Alternative | about alternative treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Zyflamend supplement for schizophrenia, -mania?

Posted by taylor18 on November 7, 2003, at 4:38:45

Article excerpt:

Schizophrenia

"The Th1-Th2 paradigm may also have relevance to the pathophysiology of schizophrenia. Norbert Muller, MD,[6] of the Department of Psychiatry and Neuropsychology, Ludwig-Maximilian University, Germany, proposed that schizophrenia is associated with an underactivation of the Th1 system and overactivation of the Th2 system. Earlier studies had shown that increases in peripheral IL-6 were associated with increased dopamine and serotonin release in the frontal cortex and hippocampus. Then it was shown that increased serum IL-6 was higher in patients with schizophrenia[7] and was associated with increased symptoms,[8] longer duration of illness,[8] and more relapses in patients with schizophrenia. Clozapine has been shown in vitro to reduce some of the elevated cytokines, including IL-6.[9] High levels of IL-10, which inhibit Th1 expression and may contribute to an underactive Th1 system, have also been found in schizophrenia. A recent study found an association between the high IL-10-producing haplotype genetic polymorphism and schizophrenia,[10] which could be a mechanism leading to an underactive Th1 system in schizophrenia. Other related work has found an association between a genetic polymorphism of the IL-1-beta and frontal and temporal gray matter volume deficits.[11]

Given that PGE2 promotes the Th2 line and has been shown to increase IL-6 release from microphages, and that cyclo-oxygenase (COX)-2 inhibitors will inhibit PGE2 and decrease IL-6 synthesis, it seemed possible that COX-2 inhibitors could be useful therapies for schizophrenia. With this mechanism in mind, Dr. Muller and colleagues[12] conducted a double-blind, placebo-controlled study of celecoxib, a commercially available COX-2 inhibitor, as adjunctive treatment of schizophrenia. All patients were also receiving 4-6 mg/day of risperidone, and celecoxib was added at 400 mg/day or a matching placebo was given for 5 weeks. The results showed a significant decrease in total positive and negative syndrome scale (PANSS) scores, a significant decrease in negative symptoms at some time points, but no difference in positive symptoms. While magnitude of improvement was modest, these results open the door to further research into augmentation strategies using immunomodulatory compounds."

Ok, pay special attention to the 2nd paragraph, specifically about the COX-2 inhibitors.

Now, take a look at Zyflamend:
http://www.new-chapter.com/product/supercritical.lasso?-database=NC_Products&-layout=Product&-response=%2fproduct%2fproduct.lasso&-recordID=22&-search

Inhibits the COX-2 enzyme and reduces inflammation*

New Chapter has extensively researched the herbal pharmacopoeia and international medical databases and discovered that the following time-tested herbs, properly extracted and blended in the correct proportions, contain at least 8 phytonutrients that may safely and significantly inhibit COX-2:*

HOLY BASIL (Ocimum sanctum) Contains the powerful COX-2 inhibitor ursolic acid, which significantly enhances detoxification and reduces inflammation.*
TURMERIC Unique curcumin phytonutrient complex, naturally inhibits inflammatory COX-2; synergistic with green tea, significantly multiplying anti-inflammatory effect of green tea polyphenols.*
GINGER Supercritical extract inhibits both inflammatory COX and 5-LO and offers numerous anti-aging constituents.*
GREEN TEA Proceedings of the National Academy of Sciences report green tea polyphenols markedly reduce COX-2.* Major university database notes green tea contains 51 anti-inflammatory phytonutrients.*
ROSEMARY Dual extracts offer highly concentrated, full spectrum, COX-2 inhibition and support detoxification.*
HU ZHANG (Polygonum cuspidatum) Richest known resveratrol source, shown scientifically to inhibit inflammatory COX-2.*
CHINESE GOLDTHREAD AND BARBERRY Unique berberine phytonutrient complex, naturally inhibits inflammatory COX-2.*
OREGANO Source of large number of anti-inflammatory compounds (31) according to USDA database.*
SCUTELLARIA Unique baicalin phytonutrient complex, naturally inhibits inflammatory COX-2.*


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Alternative | Framed

poster:taylor18 thread:277388
URL: http://www.dr-bob.org/babble/alter/20031104/msgs/277388.html