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Re: Vortioxetine revisited at 20 mg

Posted by undopaminergic on January 23, 2024, at 10:38:14

In reply to Re: Vortioxetine revisited at 20 mg, posted by SLS on January 8, 2024, at 12:15:36

> Hi.


> Memantine produced no noticeable improvement for me. I'm pretty sure I used the maximum recommended dosage.

It is my experience and understanding from what I've read, that the initial dose, if sufficient, should make you feel "weird".

My first dose was 10 mg, and I did feel weird, so I did not take more, until weeks or months later, and then it produced a nice antidepressant response, without any "weirdness". I don't recall whether my second dose was 10 or 20 mg.

At a (months) later point, I needed 60 mg, so the maximum recommended dose may not be sufficient. I survived an overdose of several grams (a gram is 1000 mg), so I would not personally worry about taking a couple of 100 mg or so on a regular basis.

> I also chose to add bromocriptine and pergolide (separately) to this combination, as both are DA receptor agonists. Both are available in the U.S. to treat Parkinson's Disease. I experienced a few days of relief before I relapsed.

Unfortunately, it may not be a good idea to take ergoline-based dopamine agonists in the longer term, as they can produce fibrosis and valvulopathy. Lilly was sued over this.

> Did any of the DA receptor partial agonist antipsychotics have any positive effects on you at all?

No, they didn't, but I never tried 2.5 mg of aripiprazole (Abilify), only higher doses.





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