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Re: Zuranalone is 'deemed' ineffective for MDD by FDA. undopaminergic

Posted by SLS on October 11, 2023, at 11:23:14

In reply to Re: Zuranalone is 'deemed' ineffective for MDD by FDA. SLS, posted by undopaminergic on October 11, 2023, at 3:58:58

> In my view, it's worth making a new drug available (if not toxic) simply because of its having a novel mechanism of action. If it does, it's almost certain to be useful in *some* cases.
>
> -undopaminergic
>\


Agreed. Unfortunately, zuranolone might be acting more like a sex steroid than any of the established antidepressants. I didn't realize this until you put up your post. It motivated me to take another look at zuranolone in the context of it possibly being specific for PPD. I decided to check if it was derived from, or acted like, a neuroactive sex-steroid. That might account for zuranolone being specific for PPD, and ineffective in MDD.

Well, it turns out that zuranolone is indeed a neuroactive steroid that is chemically related to allopregnanolone, a sex hormone precursor. Both zuranolone and allopregnanolone act as a positive allosteric modulators of GABA-A receptors. I don't have time to think about this right now. I have to get ready for a move.

I am disappointed by what I found today.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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poster:SLS thread:1122241
URL: http://www.dr-bob.org/babble/20230117/msgs/1122246.html