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Re: nortriptyline+sertraline+methylphendate undopaminergic

Posted by SLS on September 5, 2023, at 7:50:28

In reply to Re: nortriptyline+sertraline+methylphendate SLS, posted by undopaminergic on September 5, 2023, at 2:19:54

Hi, Folks.

> > > Looking for feedback on this as a possible combination...Or if I take just two of them, which ones would be the best and safest to take long term.
> > > Thanks
> >
> > I can't speak to the benefits of taking methyphenidate to produce a true antidepressant effect, even when used in combination with other medications. It most often gives someone more mental energy, but that seems to be more of a palliative measure than a therapeutic one. Have you read or heard of methylphenidate producing a true remission? I just haven"t personally seen miracles with it. If it helps palliatively onle, it makes sense to use it until you find an effective antidepressive treatment.
> >
>
> I'm not sure how you differentiate palliative and therapeutic.


This might be a useful example:

Social Anxiety Disorder:

- Therapeutic (Nardil): The remission of all psychological and somatic symptoms of Social Anxiety Disorder.

- Palliative (Xanax): A treatment modality that is meant to reduce the symptoms of anxiety in Social Anxiety Disorder while searching for an effective treatment for the disorder itself.


> Methylphenidate (and the like) produces a fast response.

Absolutely, but you have not attained remission with any of them. Why else would you stop taking them? These drugs are only of palliative value to you. Any other semantics are moot.

Like I said, you can give 10 different people the same drug and get 10 different reactions. I imagine a very, very small percentage of people glean a true therapeutic antidepressant response using methylphenidate monotherapy. At best, methylphenidate serves as a true adjunct to other drugs to produce a true remission. This is not the case with you, though. For you, I see methylphenadate as being palliative.

Since I'm not inside you, I can't know what remission feels like for you. I only know what it feels like for me. I'm not entirely sure that you know what remission feels like for you, though. You may have forgotten. If you can remember a time when you felt best, either before or after the onset of your illness, it might be critically important for you to re-experience that state of consciousness. It would serve as a means by which any current treatment can be measured and evaluated by you. Remembering what it felt like to have my mind free of depression served as my carrot, with uncertainty being my source of hope.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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