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Re: Partial response to vortioxetine (Brintellix) Jay2112

Posted by undopaminergic on August 29, 2023, at 3:33:03

In reply to Re: Partial response to vortioxetine (Brintellix) undopaminergic, posted by Jay2112 on August 28, 2023, at 22:13:14

> Hi U/D,

Hi Jay.

> Glad you are feeling a bit better. Could you not add a small, even tiny, dose of pramipexole? Did the pramipexole predispose you to a mania or psychosis? Otherwise, I think that would be a spot-on combination. I, too, found Brintellix to leave me with a similar set of feelings as you described, with that poverty of thought. Or, how about Ritalin? I believe you had said you had a positive response to that med.

I used to respond well to dopamine reuptake inhibitors, including methylphenidate (Concerta; Ritalin). It helped with apathy, including the poverty of thought. At some point, I stopped experiencing the same benefits from these drugs. However, co-administration of high doses (like 500+ mg) of caffeine restored the effects.

If I had access to pramipexole and/or stimulants, I might well try adding them.

> p.s. Besides pramipexole and Ritalin, have you tried any other dopamine agonists?

Cocaine-like: desoxypipradrol (2-diphenylmethylpiperidine, 2-DPMP) and ethylphenidate; amphetamine-like: phenylethylamine (PEA); precursors: phenylalanine, tyrosine, and L-dopa; MAOIs: selegiline. I've combined some of these, eg. selegiline + PEA.




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