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Re: Partial response to vortioxetine (Brintellix) SLS

Posted by undopaminergic on August 16, 2023, at 10:37:36

In reply to Re: Partial response to vortioxetine (Brintellix) undopaminergic, posted by SLS on August 16, 2023, at 8:44:11

> Hi, UD.

Hi, SLS.

> An ultimately successful treatment often starts with a brief improvement during the first two weeks (often within 7 days), only to disappear. However, my doctors at the NIH told me that this is considered by them to be a "blip improvement", and predictive of eventual success.

Yes. I had the blips early on, and they were transient. Now, months later, I'm responding more substantially. This second "batch" of reactions came soon after a dose increase, so with an earlier dose elevation I might well have responded much sooner.

> Unless you feel worse or have intolerable side-effects that don't mitigate over time, it is worth sticking with it - at least for 6 weeks.

I've been on it since 9 Dec 2022, although I started at only 5 mg/day.

> Vortioxetine, as I'm sure you are aware, hits almost every serotonin receptor, some as an agonist and some as an antagonist. Initially, researchers were focused on 5-HT7 receptors. I don't know if the consensus on this has changed.

The 5-HT7 receptor blockade, on its own, does not produce much of an effect. I know this because I tried lurasidone (Latuda).

I'm less certain about 5-HT3 blockade. I think it may have been involved in my early reactions to vortioxetine.

> I don't know if you believe that prayer serves any purpose, but I prayed for you anyway.

Thank you.

> The best of luck!

And thank you!





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