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Re: Many drugs likely cause changes to dopamine system Jay2112

Posted by SLS on July 7, 2023, at 9:45:07

In reply to Many drugs likely cause changes to dopamine system, posted by Jay2112 on July 5, 2023, at 19:08:21

I forgot to add that I had never heard of nortriptyline causing nightmares, vivid dreaming, and acting out my dream in bed with unrestrained movement. Many times, I wake up to the sheets on the floor. I can't do without nortriptyline, so, if I decide to do anything about it, I would first try adding prazosin, which is often used to quell nightmares in PTSD. I actually tried it about 10 years ago for my depression, the genesis of which included childhood adversity in the form of physical and emotional abuse. Prazosin, to my surprise, had a moderate antidepressant effect such that I continued to take it for about a year. For me, prazosin had no side effects at all. My doctor's rationale for choosing it is that childhood adversity resulted in what had been called "developmental PTSD", which I found to be a great term to use. Now, it has been replaced with "Complex post-traumatic stress disorder" or CPTSD. Since prazosin at higher dosages effectively treats daytime depressive and anxiety, and the possibility that there was a PTSD component to the environment I grew up in, prazosin made sense to him to try. He was good with coming up with ideas that were outside the box.

For PTSD related nightmares, one dose of 1-3 mg just before bedtime works extremely well for many people. More recently, doctors have found that 30-40 mg/day t.i.d. also works to reduce daytime aspects to the disorder. I forgot. I think prazosin reduces sex-drive to some extent, but, for me, did not abolish it.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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