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Re: Antidepressants to combine with Effexor?

Posted by SLS on April 14, 2023, at 17:12:43

In reply to Re: Antidepressants to combine with Effexor? Roslynn, posted by Jay2112 on April 14, 2023, at 15:58:00

> > Hi all,
> >
> > Does anyone know of any antidepressants that can be combined with Effexor (besides Wellbutrin and Remeron)?
> >
> >
> > Thank you for any help.
> >
> > Roslynn
> Hi Roslynn,
> Amitriptyline and imipramine are two good sedating antidepressants you can take at bedtime with Effexor. Amitriptyline is still considered the most effective antidepressant in the world, by the WHO (World Health Organization), and is listed on the WHO's essential medication list.
> For me, Prozac (fluoxetine) has also been a go-to med to combine with my Effexor. Also, if you are looking to treat anxiety, a non-antidepressant, Lyrica, has worked quite well.
> Let us know how you make out. :)
> Best,
> Jay

Over the years, I have come to the conclusion that clomipramine is the most effective tricyclic in the world to treat depression, even though the drug company wanted it to be approved for only Obsessive-Compulsive Disorder. I believe that this was just a marketing strategy. It is supposed to be more effective than amitriptyline for depression.

In the 1980s, doctors used to prescribe clomipramine (Anafranil) to their patients who were treatment-resistant. It hadn't been approved in the U.S., but Baron Shopsin hooked me up with a pharmacy in Canada. For me, clomipramine was no more effective than any of the other TCAs I had tried. However, I don't respond well to any drug treatment that doesn't include a MAOI. I did notice a moderate reduction of my sex-drive, presumably due to the ability of clomipramine to potently inhibit the reuptake of serotonin (5-HT). However, at age 25, I seemed to have plenty left. Clomipramine is perhaps the "dirtiest" of the TCAs. I did not like the way I felt on it, mostly because of side effects. It's a pretty strong anticholinergic.

I don't doubt that amitriptyline is the most effective TCA that is FDA-approved to treat depression. However, it is approved for treating depression in other countries.

At the moment, I consider clorgyline to be most effective antidepressant in the world - although it is no longer available for human consumption. For me, it was much more potent than any of the other MAOIs I have tried. At the time, I was a research patient at the National Institutes of Health. They reserved clorgyline for people who responded to nothing else. Mark Schmidt called it their "ace-in-the-hole". Clorgyline is an irreversible and specific (as opposed to selective) inhibitor of MAO-A. It is a great biological probe that is still used on rats. Lucky rats.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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