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Re: Dayvigo SLS

Posted by undopaminergic on April 2, 2023, at 8:17:05

In reply to Re: Dayvigo undopaminergic, posted by SLS on April 1, 2023, at 12:25:54

> Hi.
>
> > > I have read of Dayvigo. It blocks hypocretin (which helps keep you awake) in the brain. I haven't tried it, but have heard of the sleepwalking. Personally, I prefer benzos for sleep.
> > >
> >
> > Benzos are effective for promoting sleep, but in my experience, it is an absolutely worthless sleep. If antihistamines work for you, I would prefer them, although they take longer than benzos to induce sleep.
> >
> > -undopaminergic
>
>
> What about Seroquel (quetiapine)? People really do well with it at low dosages - 25-50 mg/day. Does it affect sleep architecture?
>

I don't know, but it's an antihistamine (H1 receptor) and a serotonin 5-HT2A antagonist. The latter does not appear to contribute to sedation, but may improve sleep quality. Cyproheptadine (Periactin) is another one that affects the same receptors.

> Benzodiazepines are supposed to affect negatively sleep architecture. I found tempazepam (Restoril)and lorazepam (Ativan) to be the best of the bunch for insomnia. I prefere Ambien (zolpidem). It impacts sleep architecture minimally or not at all - especially REM sleep. Ambien puts me to sleep quickly and with no hangover the next morning.
>

It used to work the same for me many years ago, but later it had little or no effect (the same is true for temazepam).

> It does have a short half-life. However, I don't experience rebound awakenings like I did with triazolam (Halcion), another drug with a short half-life. For this reason, I took both lorazepam and triazolam. Triazolam put me to sleep and lorazepam kept me asleep. I needed this to remedy total insomnia while I was taking a combination of Parnate + desipramine.
>
> Another drug that might be worth looking at isto treat insomnia is trimipramine (Surmontil). In contrast to other tricyclic antidepressants, trimipramine:
>
> 1. Increases sleep efficiency.
>
> 2. Does not reduce REM sleep, and tends to enhance it.
>
> 3. Does not inhibit the reuptake of norepinephrine-NE (noradrenalin-NA), serotonin (5-HT) or dopamine (DA).
>
> 4. Has mild antipsychotic effects.
>

"Substantial" according to a German study comparing it to perazine.

> 5. Produces very little rebound insomnia upon discontinuation.
>
> 6. Is tolerated better than doxepin.
>

It also reduces cortisol secretion.

-undopaminergic


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poster:undopaminergic thread:1121942
URL: http://www.dr-bob.org/babble/20230117/msgs/1121976.html