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Re: Dayvigo undopaminergic

Posted by SLS on April 1, 2023, at 12:25:54

In reply to Re: Dayvigo Jay2112, posted by undopaminergic on April 1, 2023, at 2:39:17

Hi.

> > I have read of Dayvigo. It blocks hypocretin (which helps keep you awake) in the brain. I haven't tried it, but have heard of the sleepwalking. Personally, I prefer benzos for sleep.
> >
>
> Benzos are effective for promoting sleep, but in my experience, it is an absolutely worthless sleep. If antihistamines work for you, I would prefer them, although they take longer than benzos to induce sleep.
>
> -undopaminergic


What about Seroquel (quetiapine)? People really do well with it at low dosages - 25-50 mg/day. Does it affect sleep architecture?

Benzodiazepines are supposed to affect negatively sleep architecture. I found tempazepam (Restoril)and lorazepam (Ativan) to be the best of the bunch for insomnia. I prefere Ambien (zolpidem). It impacts sleep architecture minimally or not at all - especially REM sleep. Ambien puts me to sleep quickly and with no hangover the next morning. It does have a short half-life. However, I don't experience rebound awakenings like I did with triazolam (Halcion), another drug with a short half-life. For this reason, I took both lorazepam and triazolam. Triazolam put me to sleep and lorazepam kept me asleep. I needed this to remedy total insomnia while I was taking a combination of Parnate + desipramine.

Another drug that might be worth looking at isto treat insomnia is trimipramine (Surmontil). In contrast to other tricyclic antidepressants, trimipramine:

1. Increases sleep efficiency.

2. Does not reduce REM sleep, and tends to enhance it.

3. Does not inhibit the reuptake of norepinephrine-NE (noradrenalin-NA), serotonin (5-HT) or dopamine (DA).

4. Has mild antipsychotic effects.

5. Produces very little rebound insomnia upon discontinuation.

6. Is tolerated better than doxepin.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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poster:SLS thread:1121942
URL: http://www.dr-bob.org/babble/20230117/msgs/1121973.html