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Re: Flupentixol undopaminergic

Posted by tensor on April 1, 2023, at 12:23:23

In reply to Re: Flupentixol, posted by undopaminergic on April 1, 2023, at 12:09:02

> I was given Truxal as a PRN option for insomnia, after I expressed concerns that levomepromazine (Nozinan) would make me tired in the morning. I guess it has a shorter duration of action. I never got around to trying it.
> I have used flupenthixol (Fluanxol) a lot. I tried it as an antidepressant starting at 0.5 mg. Later, they insisted that I needed neuroleptics, and Fluanxol was one of my suggestions. Alas, I did not notice an antidepressant effect, but it also didn't seem to yield the sedation that is so common with many antipsychotics. At several milligrams it produced inorgasmia, and some motor restlessness, but not akathisia.
> -undopaminergic
Do you have a favorite among the FGAs? Do you suffer from anxiety disorders, if so, did Fluanxol help with that?
If I understood correctly flupentixol binds somewhat to 5HT2A and 5HT2C, but not as much as chlorprothixene. I wonder if some of the other medications I take can mitigate s/e such as EPS and akathisia (I have not yet experienced it from these two APs), like fluoxetine, mirtazpine and nortriptyline all have this property (5HT2A antagonist).
Could they make a typical AP more atypical? Is the risk for TD reduced?
45mg Truxal didn't effect my sexual ability, ie erection and orgasm. But it's a low dose.

Thanks for your input.





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