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Re: to sls again rose45

Posted by SLS on March 17, 2023, at 10:37:42

In reply to to sls again, posted by rose45 on March 16, 2023, at 15:22:03

Hi, Rose.

Let me know how you are doing. I posted another message to you just above this one:

http://www.dr-bob.org/babble/20230117/msgs/1121923.html

Please let me know how your outlook has changed after reading it.

I think your first job is to think of ways to navigate the NHS regulations. You will need to find a doctor willing to prescribe Nardil in combination with other drugs, especially TCAs. For me, I absolutely do not respond well to any treatment unless it combines MAOI + TCA. You would want to limit your selection of TCAs to nortriptyline, desipramine, amitriptyline, and doxepin. Trimipramine might be okay, too, but I don't know of anyone who has tried it combination with a MAOI. However, the drugs that you absolutely must avoid when taking a MAOI are ANY that include as one of its properties, serotonin (5-HT) reuptake inhibition.

Examples:

SSRI
SNRI
imipramine
clomipramine
vortioxetine
vilazodone
trazodone
milnacipran
Levomilnacipran
5-HT receptor agonists?

* Fenfluramine (FINTEPLA) has been used for weight-loss, but was taken off the market because it caused heart valvulopathy (damage to heart valves). This is not due to serotonin receptor agonism (stimulation). Instead, it is caused by 5-HT2B receptor antagonism (blocking).

* The most dangerous drugs to combine with MAOIs are 5-HT reuptake inhibitors. Serotonin Syndrome is often the result. The only drug I know of that can be used as a remedy for Serotonin Syndrome is cyproheptadine (Periactin). There may be others.

If you haven't tried lithium at dosages above 150 mg/day, you absolutely must try 300-450 mg/day.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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poster:SLS thread:1121922
URL: http://www.dr-bob.org/babble/20230117/msgs/1121924.html