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Re: Is there any evidence that Trazodone curbs OCD?

Posted by SLS on January 21, 2023, at 9:16:50

In reply to Re: Is there any evidence that Trazodone curbs OCD?, posted by Lamdage22 on January 21, 2023, at 5:26:46

> > > > Can anyone interpret the evidence? From what I can tell, it doesnt help much.
> > >
> > > No, not really. It was the 'med from hell' for me, BUT, I LOVED it's sister drug, nefadozone!! The most UNHARSH antidepressant. Marketed as Serzone in N.America. Don't know about it's effect on OCD, but it has calming effects via 5ht2a blockade.
> > >
> > > Jay
> > >
> > >
> >
> > It seems it is actually an *agonist* at the serotonin 5-HT2C receptor:
> >
> >
> > That would translate to an antidopaminergic effect.
> >
> > -undopaminergic
> Is that good or bad? There is evidence that Neuroleptics can agitate OCD. I feel they do that with me.

Be aware that priapism is a possible side-effect of trazodone. As attractive as this might be to some males, it is actually a medical emergency.

The other thing worth mention is that a major metabolite of trazodone is 1-PP. It can be a nasty substance that elicits anxiety and other unwanted side effects. Look into it for a comprehensive overview of 1-PP.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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