Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Lithium effects on hippocampal glutamate

Posted by undopaminergic on January 1, 2023, at 17:37:19

I just read this study:
Title: "Bimodal effect of lithium plasma levels on hippocampal glutamate concentrations in bipolar II depression: a pilot study".
The full article is available.

My interpretation is that lower plasma lithium concentrations (< 0.50 mmol/L) are associated with a reduction of glutamate levels in the hippocampus, while higher lithium concentrations (>= 0.50 mmol/L) are associated with an increase. I would not have expected this.

Note that the lithium doses were individualised, and that the changes in glutamate levels were not correlated with the changes in depressive severity. Apparently, some people feel better with a reduction in hippocampal glutamate and others with an increase. This is hardly surprising.





Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:undopaminergic thread:1121444