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One Drug - Opposite Effects - Different brain?

Posted by SLS on December 31, 2022, at 16:55:36

I have never seen the following taken into consideration. None of my doctors ever did. However, it is really just common sense.


* A single drug can have opposite effects depending on the drug that preceded it.


Something very curious happened to me after I failed to respond to vortioxetine. I switched immediately to Effexor without a waiting period. For all practical purposes, I had been used in an experiment in which vortioxetine was used as a pre-treatment to a challenge by Effexor. Of course, the dynamics of brain function were altered by vortioxetine before Effexor was introduced. Although the pharmacodynamics of Effexor were exactly the same, it wasn't being introduced to the same brain. It acted like a completely different drug than the one I was familiar with. It significantly increased the severity of depression and left me in a brain-fog that came close to feeling like derealization. It took about 2 weeks for my head to clear after I discontinued Effexor.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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