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Re: Tolerance is just so low!! SLS

Posted by undopaminergic on December 29, 2022, at 10:34:05

In reply to Re: Tolerance is just so low!! undopaminergic, posted by SLS on December 28, 2022, at 21:20:47

> You make my brain hurt.

How so?

> What is your impression of zuranolone? Before I hit pay-dirt with my current drug regime, zuranolone was the drug I was most interested in. All I know about it pharmacologically is that it is described as a positive allosteric modulator of GABA-A receptors. Zuranolone works to potentiate GABA-mediated currents. I imagine you know more than me about proposed role of GABA in depression.

I'd say I probably don't. But I am aware that anxiety is often comorbid with depression, and it can "feed" the depression. Ie. the anxiety makes you feel lower. So treating the anxiety with GABAergic drugs (including zuranolone) can ameliorate (part of) the depression.

> From what I understand, zuranolone increases the reactivity of GABA-A receptors, thus potentiating GABA currents. How might the stimulation of GABA-A receptors manifest?

Maybe like benzodiazepines?

Benzodiazepines increase the frequency of GABA chloride channel opening, and barbiturates prolongs the opening. Do you know how zuranolone works?

> In clinical trials, zuranolone was reported by the manufacturer to be effective in treating Major Depressive Disorder, Bipolar Depression and Post-Partum depression. I don't know which indications(s) SAGE Pharmaceuticals will apply for.
> - Scott

I'd be interested in trying it but I'm not particularly excited about it.





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