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Re: Tolerance is just so low!! undopaminergic

Posted by SLS on December 28, 2022, at 21:20:47

In reply to Re: Tolerance is just so low!! SLS, posted by undopaminergic on December 28, 2022, at 16:40:08

You make my brain hurt.

What is your impression of zuranolone? Before I hit pay-dirt with my current drug regime, zuranolone was the drug I was most interested in. All I know about it pharmacologically is that it is described as a positive allosteric modulator of GABA-A receptors. Zuranolone works to potentiate GABA-mediated currents. I imagine you know more than me about proposed role of GABA in depression. From what I understand, zuranolone increases the reactivity of GABA-A receptors, thus potentiating GABA currents. How might the stimulation of GABA-A receptors manifest?

In clinical trials, zuranolone was reported by the manufacturer to be effective in treating Major Depressive Disorder, Bipolar Depression and Post-Partum depression. I don't know which indications(s) SAGE Pharmaceuticals will apply for.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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