Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Mice lacking 5-ht2c unlearn fear faster

Posted by iforgotmypassword on December 7, 2022, at 15:57:19

In reply to Mice lacking 5-ht2c unlearn fear faster, posted by linkadge on December 5, 2022, at 14:04:27

What i recall from reading abt this recently given 5-ht2c seems to b the disaster receptor responsibile for ssri akathisia, bruxism etc that chokes DA efflux from VTA:

-forget risperidoneits actually pretty weak. U need higher 2c affinity than 2a to get significant occupancy at 2c receptors, and saturation with inverse agonism seems to b required to get the pro-DA anti-EPS effect you see in animal models; risperidone is also one of the harshest antipsychotics ive ever taken on movement

-this leaves clozapine, mirtazapine, and maybe asenapine and sertindole but i doubt they are as gentle on movement as clozapine




Post a new follow-up

Your message only Include above post

Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.


Start a new thread

Google www
Search options and examples
[amazon] for

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:iforgotmypassword thread:1121215