Psycho-Babble Medication | about biological treatments | Framed
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Re: Tolerance is just so low!!

Posted by SLS on November 21, 2022, at 7:39:17

In reply to Re: Tolerance is just so low!!, posted by SLS on November 21, 2022, at 7:10:32

I forgot to mention that I have personally experienced a clonidine-induced exacerbation of depression.

Most salient, though, is that clonidine is capable of producing significant depression in people who have no history of depression.

1. Clonidine = (norepinephrine) NE alpha-2 presynaptic autoreceptor agonist (stimulatior).

2. NE alpha-2 receptors control the manufacture and release of NE via a negative feedback loop.

3. When NE presynaptic autoreceptors are antagonized (blocked), the presynaptic neuron increases the manufacture and release of NE. This is because the presynaptic neuron "sees" less synaptic NE than there actually is by blocking its "eyes" (autoreceptors) from accurately measuring synaptic NE levels. It sees less than there really is. The neuron is thus fooled into manufacturing and releasing more NE.

4. When NE autoreceptors are agonized (stimulated), the presynaptic neuron "sees" more synaptic NE than there really is. The presynaptic neuron thus reduces its manufacture and release of NE to compensate.

5. Clonidine thus reduces the synaptic concentration of NE by stimulating presynaptic autoreceptors.

6. Reduced synaptic concentrations of NE are associated with depression.

* I hope I got that right.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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