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Re: Another interesting combination treatment.

Posted by undopaminergic on August 27, 2022, at 10:36:17

In reply to Re: Another interesting combination treatment., posted by linkadge on August 27, 2022, at 6:41:09

> >I haven't a clue as to how bupropion and minocycline might have a synergistic effect.
>
> I suppose the idea is that bupropion doesn't address microglial inflammation on its own. Some antidepressants are better in this regard than others.
>
> The problem with brain inflammation is that it can significantly reduce the ability of neurotransmitters to do their work. I read a recent study that showed that by inducing brain inflammation by using lipopolysaccharide, synaptic responses to dopamine are significantly reduced.
>
> Linkadge

What about corticosteroids and NSAIDS?

Incidentally, corticosteroids can induce a condition known as "steroid euphoria". But cortisol is reportedly bad for the brain, especially the hippocampus.

-undopaminergic


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poster:undopaminergic thread:1120486
URL: http://www.dr-bob.org/babble/20220530/msgs/1120497.html