Posted by SLS on June 7, 2022, at 20:41:03
In reply to Re: Oral deprenyl vs bupropion? - More, posted by undopaminergic on June 7, 2022, at 7:47:04
> > I forgot to mention that taking L-deprenyl / selegiline orally is not terribly effective. I tried sit many years ago. I don't remember the pharmacological reasons for this, but I believe oral administration produces far less circulating selegiline. I think it might be broken down in the gut.
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> The first-pass metabolism in the liver converts much of it to l-methamphetamine, l-amphetamine, and desmethylselegiline, but these metabolites are also responsible for some of the pharmacological effects of selegiline. I think the initial mood boost I got from it was due to the amphetamines. Research has revealed that a lot of the neuroprotective properties of selegiline are due to desmethylselegiline, which is also a MAO-B inhibitor.
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> -undopaminergic
Good info, U_D. It has been a long time since I tried EMSAM. I don't remember much about it.I began studying L-deprenyl in 1983. At the time, I was looking for anything that would boost dopamine. The research clinician who I was seeing at Columbia-Presbyterian laughed at me. Her only comment when I asked her about using bromocriptine was that I would have fun throwing-up all day. At the time, there was only one other publishing author who began to focus on the possible role of dopamine in depression. His name was A. Randrup. He was at the University of Chicago at the time. I was reassured to find someone with letters after his last name coming to the same conclusions.
https://pubmed.ncbi.nlm.nih.gov/408861/
- ScottSome see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1119824
URL: http://www.dr-bob.org/babble/20220530/msgs/1119855.html