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Re: Any experiences w/ Riluzole for depression?

Posted by undopaminergic on June 6, 2022, at 10:45:52

In reply to Any experiences w/ Riluzole for depression?, posted by PeterMartin on June 4, 2022, at 22:06:53

> Has anyone here tried Riluzole (ALS medication) off label for depression, anxiety, or OCD?
> I only learned about it today while reading a paper on experimental medications for depression. Is it something that could be combined w/ other medications like an SSRI or in my particular case an MAOI?
> Thanks for any discussion.

I've never used it or read much about it, but it is apparently an antiglutamatergic agent, with both pre- and post-synaptic mechanisms of action. It may possibly complement drugs from other classes (such as SSRIs and MAOIs). I don't know about risks or efficacy, but there is almost certainly individual variation, as with other drugs, and to know how it will affect you, there is no alternative to trying it.





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