Posted by undopaminergic on June 6, 2022, at 10:30:21
In reply to Re: Started oral ketamine » SLS, posted by beckett2 on June 4, 2022, at 16:51:11
>
> It's like not having been depressed. At first, the feeling was very strange, like, wtf? As someone w bipolar ll, there is no hypomania.
>That's interesting. I'm bipolar and while I've never had the chance to try ketamine, I've used memantine, another NMDA-glutamate antagonist, and it induced a manic state leading me to do very stupid, impulsive things that landed me in hospital (first somatic and then mental).
As SLS suggests, I think you're right not to take it every day, both to avoid potential issues with tolerance and loss of efficacy, and for reasons of safety. In rodents, ketamine (and PCP and MK-801 but not xenon or memantine) can induce neurotoxicity (known as Olney's lesions) in the retrosplenial cortex. Chronic use can also destroy the bladder in humans.
-undopaminergic
poster:undopaminergic
thread:1119828
URL: http://www.dr-bob.org/babble/20220530/msgs/1119845.html