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Re: Radical new theory..Inflamation causes depression.

Posted by SLS on May 25, 2022, at 6:37:23

In reply to Radical new theory..Inflamation causes depression., posted by Jay2112 on May 25, 2022, at 2:11:12

> I have been experimenting lately...mostly with larger doses of anti-inflammatory drugs (NSAIDS) for some of my brutal headaches and body aches. Done a couple times a day, it feels like a major 'lift', enabling me to great extents. And it brings, surprisingly, a relief to my mind.
> -----------------------------------------
> The Inflamed Mind: A Radical New Approach to Depression Edward Bullmore Short (2018)
> Depression affects one in four people at some time in their lives. It is often difficult to treat, in part because its causes are still debated. Psychiatrist Edward Bullmore is an ardent proponent of a radical theory now gaining traction: that inflammation in the brain may underlie some instances. His succinct, broad-brush study, The Inflamed Mind, looks at the mounting evidence.

Not so new. Not so radical. But...

Monocycline is a particularly good anti-inflammatory that reduces the release of pro-inflammatory cytokines from microglia cells in the brain. I found it helpful enough to take it for over a year. However, one of the possible side effects of monocycline is hyperpigmentation of the feet and shins. It looks like dirt or black-and-blue marks, and is sometimes irreversible. It usually doesn't show up for a year or more of taking it continuously.

There have been a few experiments using celecoxib (Celebrex), a NSAID that is specific for COX-2, in depression. The few things I read about this treatment indicated that it wasn't robust enough to look into it further.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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