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Re: Psychedelics - Mechanisms linkadge

Posted by SLS on March 24, 2022, at 21:07:34

In reply to Re: Psychedelics - Mechanisms, posted by linkadge on March 24, 2022, at 15:20:50

> >I think it is important to note that psychedelics >are *partial* agonists at 5-HT2A receptors. >Serotonin is a full agonist and has no (or very >little) psychedelic potential. The antagonists, as >far as I'm aware, are "full antagonists". So you >would expect drugs that block 5-HT2A to antagonise >psychedelics dose-dependently.
>
> From what I understand too, there are some difference in the localization and/or function in 5-ht2a receptors that respond to serotonin vs. hallucinogens. Something about how hallucinogens active different 2nd messenger systems than serotonin. Way above my head.

I'm pretty sure it isn't. :-)


That's interesting stuff.


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.

 

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