Posted by Jay2112 on January 16, 2022, at 17:34:34
In reply to Re: Esmethadone helps treatment-resistant depression, posted by SLS on January 11, 2022, at 21:25:59
> > >
> > > What do you think of this compound?
> >
> > It has an interesting name that makes me wonder if this stereoisomer is part of ordinary methadone. Apparently it has no opioid effects.
> >
> > > It might be worth finding out in what ways it differs from memantine. Memantine pretty much sucks as an depression. It is equally dismal as an anti-Alzheimer's drug.
>
> > Memantine actually worked "too well" in my experience, inducing a manic condition.
>
> My doctor once said that if a given drug never triggers mania in at least some people, it would be relatively ineffective as an antidepressant in general. Sometimes, triggering a hypomania using an antidepressant is the first step in bringing someone out of a refractory depression. The second step is to use an antimanic agent to cap the hypomania while continuing the antidepressant. For some people, their hypomania, if not impacting their life negatively, are left feeling euphoric, having enormous energy, and accelerated thinking. They are often hyperfunctional. Why rock the boat?
>
>
> > Finding the right dose was difficult. First it worked at less than 10 mg and later I needed about 60 mg. I wonder how high it would have gone if I had kept using it. The reason I didn't was my impulsive massive overdose of it, which was a more or less direct result of the mania. I left the container in plain sight and it was gone when I came back home after hospitalization.
>
> I found myself compulsively changing the dosage of Nardil up and down. It was a bad habit I picked up from one of my doctors in the 1980s.
>
> Ouch.
>
>
> > It may have applications in Parkinson's disease and tolerance to amphetamines and opioids.
> >
> > -undopaminergic
Hugh, Scott and UD:Methadone, it's isomer being esmethadone, is a very good choice of an antidepressant, in particular at low doses. So, I think esmethadone should have SOME opioid receptor agonism. It makes its therapeutic effects better, I would naturally think. I have been on trials of methadone, but for a few reasons, were discontinued because I didn't like having to go to the methadone clinic every day to get the stuff. (In a juice drink formulation.) My buddy has been on it for a year, and has lost tons of weight, and relieved his depression and anxiety.
I hope this is widely available soon without the god damn restricted/listed drug. I am SO SICK, and I say this as a mental health/addictions worker, of the stereotype mentality of ANY drug. We need like Portugal...delist/unrestrict EVERY drug out there...get pharmaceutical quality of EVERY drug, and just prescribe the damn stuff..NO bounds..
Jay
Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-
poster:Jay2112
thread:1118094
URL: http://www.dr-bob.org/babble/20211102/msgs/1118174.html