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Re: Esmethadone helps treatment-resistant depression

Posted by Hugh on January 11, 2022, at 20:47:00

In reply to Re: Esmethadone helps treatment-resistant depression SLS, posted by Hugh on January 11, 2022, at 20:41:21

The therapeutic potential of esmethadone was first identified and explored at New York Presbyterian/Weill Cornell Medicine. Researchers observed that when esmethadone was tried in late-stage cancer patients, their pain did not improve but there were positive effects on mood. In parallel, we were learning more about the NMDAR's role in depression. Since then, phase 1 and 2 studies have supported esmethadone's continued development as a potentially safe, effective antidepressant with quite rapid onset. However, these very encouraging results need to be further confirmed in larger and longer phase 3 studies. Relmada Therapeutics, Inc is currently conducting these studies as part of our RELIANCE Clinical Research Program.

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