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Re: Esmethadone helps treatment-resistant depression SLS

Posted by undopaminergic on January 11, 2022, at 12:23:52

In reply to Re: Esmethadone helps treatment-resistant depression Hugh, posted by SLS on January 11, 2022, at 11:03:19

> What do you think of this compound?

It has an interesting name that makes me wonder if this stereoisomer is part of ordinary methadone. Apparently it has no opioid effects.

> It might be worth finding out in what ways it differs from memantine. Memantine pretty much sucks as an depression. It is equally dismal as an anti-Alzheimer's drug.

Memantine actually worked "too well" in my experience, inducing a manic condition. Finding the right dose was difficult. First it worked at less than 10 mg and later I needed about 60 mg. I wonder how high it would have gone if I had kept using it. The reason I didn't was my impulsive massive overdose of it, which was a more or less direct result of the mania. I left the container in plain sight and it was gone when I came back home after hospitalisation.

It may have applications in Parkinson's disease and tolerance to amphetamines and opioids.





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