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Re: Vortioxetine (Brintellix-Trintellix) undopaminergic

Posted by SLS on November 17, 2021, at 9:55:34

In reply to Vortioxetine (Brintellix-Trintellix), posted by undopaminergic on November 13, 2021, at 12:31:24

> Hi all,

Hi, UD.

> I've decided that vortioxetine is worth a try, despite the failure of lurasidone (Latuda) which shares some of the serotonin antagonism (5-HT7 to be specific). It could be that the serotonin 5-HT3 is key, and the only way to know is to try. Memantine is another antagonist at this receptor, and as some of you may recall, it made me manic; I thought it was the NMDA-glutamate antagonism, but I had horrible effects (worst dysphoria I've experienced) with methoxetamine, a powerful NMDA-antagonist. I have yet to try ketamine.
> It does help some people with treatment resistant depression. Here is a sample from "I have been taking 20 mg for about 1 month. I feel awesome. I have taken everything you can imagine and no success.".
> Most of the reports on this forum seem to have been negative; has anyone had any promising effects from it?

Vortioxetine didn't help me at all. It didn't make the depression itself worse, but it left me in a profound state of brain-fog.


Immediately after I switched from vortioxetine to Effexor, my depression became dramatically worse, and I decided to commit suicide. This is as close as I ever came to doing it. I was at a friend's house, and, of course, I wasn't going to leave her with my dead body to deal with. I had NEVER had a negative reaction to Effexor during the five or more times that I had taken it. It sometimes helped. My best guess is that pre-treatment with vortioxetine set the brain up for this severe reaction to Effexor. If vortioxetine were a wonder-drug, I think we would all have known it by now.

My advice to you is that you try it vortioxetine if you have run out of options that have a low probability of working. You never know.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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