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Re: What are the consequences of inhibiting LTP?

Posted by undopaminergic on October 11, 2021, at 15:29:53

In reply to Re: What are the consequences of inhibiting LTP?, posted by linkadge on October 8, 2021, at 18:16:33

> It is interesting because I have read studies suggesting that venlafaxine both inhibits LTP and increases neurogenesis. I don't know the clinical significance of inhibiting LTP as venlafaxine has been shown to improve memory in a number of studies:

You seem to know a lot about venlafaxine. Have you tried it yourself?

> My hunch is that venlafaxine tips the balance between acetylcholine and monoamines in the hippocampus. Acetylcholine can strengthen LTP but it can also induce depression.

Yes. I read about a hypercholinergic mouse model of depression many years ago, but when, recently, I tried to look into it again, I could not find anything.

I think I may be hypercholinergic. My pupils are always small and I seem to be undersensitive to anticholinergics.

> For me, the best antidepressants completely wipe my memory out. For me, weed works when nothing else does, and I feel the best when I can barely remember my own name.
> Linkadge

Have you tried anticholinergics? I seem to recall that you had belladonna extract?





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