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Need advice...nortriptyline

Posted by jay2112 on July 24, 2021, at 15:31:23

Hi everyone:

Well, I am on a combo of Effexor, Remeron, and nortriptyline. Have been for over a month.

Now, I am, I guess, 'mild' asymptomatic, with a major reduction in my cPTSD (complex PTSD) symptoms, in particular a reduction in consistent crying, and extreme vegetative symptoms. As well as startle effect, and freezing behaviour.

But, I DID, when started notrip, go out for regular tasks (reduced agoraphobia) and felt less pain (I am anemic, and can't take iron suppliments because of kidney disease.) But now, a month later, I am having increased pain, apathetic symptoms (like on an SRI), anhedonia has returned, and increased diarrhea (despite notrip's anticholinergic properties..also like an SRI symptom). I have to mention, these effects are above and beyond my original Rx of Effexor and Remeron, which I have been on, in a combo, for over 5 years. (Sorry, I forgot to mention that I am also on Vyvanse, for over 11 years.)

The notriptyline isn't even giving me the bottom end boost it did when I was on fluoxetine for over 10 years. That is what I am looking for, that 'anti-lethargic' feeling I got from nortriptyline. It gave me the boost sort-of like (but smoother) that I got from Vyvanse.

Take-away: should I boost the nortriptyline (which I did, recently, with only major caffeine-like jitters, which I *absolutely HATE*.) or add some other kind of norepinephrine/dopamine boosters?
One of the problems,which I hate, and think contributes to tolerance and failure of many drugs, is downregulation of the receptors.

Should I possibly try a small amount of l-tyrosine, or l-phenylalanine, (d-phenylalanine didn't make any difference in the past.)? I am honestly looking for complementary alternatives, as I have tried about 98 percent of psychiatric Rx's available in Canada. *Note...I have also tried increasing all of these doses, as well as dropping one med at a time for a minimum of 4-6 weeks, with mostly nasty side-effects.


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-




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poster:jay2112 thread:1116085