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Re: Antibiotics for most mental illness

Posted by SLS on July 11, 2021, at 7:25:09

In reply to Antibiotics for most mental illness, posted by jay2112 on July 3, 2021, at 20:24:51

> So, I know this has been discussed on here before, but your thoughts, everyone?

Minocycline helped me perceptibly over the course of months. I had to discontinue it because of the development of black and blue discolorations of the skin. It's called hyperpigmentation, and usually appears on the feet and shins.

There is sometimes a residual hyperpigmentation that doesn't disappear. Most of mine disappeared, but it took months.

What about Lyme Disease? Believe it or not, some Lyme experts have seen disulfiram (Antabuse) effectively treat Lyme when antibiotics didn't. Just stay away from alcohol. Treating Lyme with doxycycline has been the standard practice. Taking doxycycline for months did not improve my depression at all. I think minocycline causes a greater inhibition of the release of microglial pro-inflammatory cytokines than doxycycline.

Over the years, NSAIDs have been studied for depression. Statistically, many studies have shown shown some therapeutic efficacy. Wishful thinking on the part of investigators? Celecoxib (Celebrex) might be worth taking a look at. Usually, this drug does not produce ulcers. This was why the drug was developed. However, celecoxib ometimes causes severe stomach pain as a side effect. I don't know the mechanism behind this. Celecoxib is a selective inhibitor of COX-2. Perhaps COX-1 inhibition is the property necessary to produce an antidepressant effect. I haven't looked deeply into this, but celecoxib has been investigated using RCT (randomized clinical trial).

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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