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Re: Major Serotonin Bias... jay2112

Posted by SLS on July 7, 2021, at 7:59:52

In reply to Major Serotonin Bias..., posted by jay2112 on July 6, 2021, at 23:20:04

Hi, Jay.

The length of your post was easily readable. Perfect length for the amount of information and your thoughts.

I empathize with your plight. It is sad and frustrating for me to read about.

It is not surprising that you should have had any kind of positive response to Effexor. Are there any drugs that produced any kind of brief or mild response for you?

At the NIH, their "ace in the hole" drug was an MAOI-A *specific* (not just selective) inhibitor called clorgyline. It is still the most potent (statistically) antidepressant in the world. They no longer provide it for human consumption because of reports of treatment-emergent cardiac events. It has never been available anywhere else in the world. At a time when my depression wouldn't budge, clorgyline helped knock a few bricks out of the wall. I don't have time to research it, but it is my impression that Nardil is the closest thing to clorgyline that is still available. Because your reaction to SSRIs includes social anxiety / phobia, Nardil seems to be worth a look at. If you tried Nardil already, and experienced any kind of positive response, you might consider using it in combination with other medications. Of course, I have a bias for using this strategy because I am having such a dramatic response to it.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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