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Re: Amphetamine for schizohprenia?

Posted by linkadge on July 1, 2021, at 13:37:38

In reply to Re: Amphetamine for schizohprenia? linkadge, posted by undopaminergic on July 1, 2021, at 7:25:48

>I've read that amphetamines reverse the >direction of the dopamine transporter, and, as >far as I understand it, also the vesicular >monoamine transporter. Do you know if these >actions have anything to do with agonism at the >TAAR1?

Good question. I don't think the two effects are directly connected. I.e. they have found TAAR1 agonists which do not affect monoamine transporters like amphetamine. However, there seems to be some cross talk between the two mechanisms. Whatever I read is totally above my head. Interestingly, the reverse transport effect though can be blocked by DAT inhibitors (like ritalin) or by PKC inhibitors (like lithium).

>Yes, but methylphenidate (and cocaine) help too >(of course not in all subjects), and it is not >a TAAR1 agonist.

That is true, although some studies link methylphenidate response to an increase in PEA (which is a TAAR1 agonist). Also, some people respond to amphetamine but not ritalin (or vice versa).




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