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Re: Amphetamine for schizohprenia?

Posted by undopaminergic on June 28, 2021, at 5:31:59

In reply to Amphetamine for schizohprenia?, posted by linkadge on June 27, 2021, at 16:20:52

> The actions of amphetamine are complex (I don't understand it myself) but they do activate a receptor called TAAR1. Interestingly, TAAR1 activation can actually reduce hyperdopaminergic function (i.e. reduce dopamine). It is hypothesized that amphetamine may for for ADHD via TAAR1 activation.
> Amphetamine is typically seen to increase dopamine, but it does have this action which does the exact opposite. It is complex but interesting.

That is roughly my understanding too, which is confirmed by the abstract of the article you link to. More specifically, agonism of trace amine associated receptors (TAARs) seems to reduce spontaneous firing of dopamine neurons, but amphetamine still (at least at higher doses) increases post-synaptic dopamine agonism through its dopamine-releasing action. I have often speculated that this reduction of spontaneous firing may, in some cases, be the underlying mechanism behind the so-called paradoxical calming effect of amphetamines in subjects with ADHD.





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