Psycho-Babble Medication | about biological treatments | Framed
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Amphetamine for schizohprenia?

Posted by linkadge on June 27, 2021, at 16:20:52

I know I've posted on this topic before, but there is a high occurrence of schizophrenia and psychostimulant abuse (particularly amphetamines).

The actions of amphetamine are complex (I don't understand it myself) but they do activate a receptor called TAAR1. Interestingly, TAAR1 activation can actually reduce hyperdopaminergic function (i.e. reduce dopamine). It is hypothesized that amphetamine may for for ADHD via TAAR1 activation.

Amphetamine is typically seen to increase dopamine, but it does have this action which does the exact opposite. It is complex but interesting.

I am certainly not recommending the use of amphetamine for people with psychotic disorders, but more a thought experiment on exactly what is going on.

TAAR1 agonists actually have antispychotic effects. I wonder if some schizophrenic patients are actually feeling more of the TAAR1 agonist effect than normal people.





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