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Re: do neuroleptics always=dysphoria?

Posted by undopaminergic on April 27, 2021, at 11:40:09

In reply to Re: do neuroleptics always=dysphoria?, posted by linkadge on April 27, 2021, at 11:14:27

> ... I also think it is possible to be satisfied without being hypermotivated.

Oh, absolutely, it's almost the opposite. I once had an experience of complete satisfaction (and the only experience of being fully relaxed, maybe the only time in my life), in connection with taking codeine cough syrup and another one containing dextromethorpan and salbutamol (IIRC aka. albuterol). I had absolutely no cravings for anything else/more. I would not say it took motivation *away* exactly -- I could still *do* things, but without the discomfort of craving.

> Crudely speaking, hypermotivated people may have a relative dominance of dopamine to serotonin. These are the people who work their *ss*s off to achieve things that they only enjoy for a few sections. For society, this is the 'ideal' type of human, but on an individual level, I don't envy a life of constant treadmill running.

Yeah, it's actually sad in a way.

> >I'd also say some dopamine receptors are very >close to producing pleasure. Pramipexole was >the only anti-anhedonic drug I tried; it's a >D3>D2 receptor agonist.
> Very true. I don't fully understand it myself. However, for some individuals, blocking dopamine might help achieve a better monoamine balance.

Likewise with other monoaminergic interventions.





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