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Histamine H2-receptor antagonism

Posted by undopaminergic on November 19, 2020, at 4:24:14

Hi all,

I was wondering if anyone has any thoughts on or experience with histamine H2-receptor antagonism.

Famotidine has shown promising results in the treatment of negative symptoms in schizophrenia. Negative symptoms are very much like depression, including apathy and anhedonia.

Trimipramine is a potent and high-affinity histamine H2-antagonist. Clozapine is an inverse agonist at the receptor.

In schizohprenia (famotidine):

In depression (ranitidine):





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