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Re: Help... levomilnacipran or vilazodone??? jay2112

Posted by linkadge on November 14, 2020, at 15:54:25

In reply to Help... levomilnacipran or vilazodone???, posted by jay2112 on November 5, 2020, at 22:35:50

I can mirror your response to 5-htp vs. tryptophan. I find tryptophan fine, but 5-htp leaves me feeling crappy. Tryptophan metabolizes to a variety of substances which can have differing effects (besides serotonin enhancement).

Levomilnacipran is a more selective towards serotonin (about 2:1). It is probably better for pain, energy, motivation, concentration etc. Whereas, vilazodone is probably better for anxiety, sleep and possibly core depressive thoughts.

It's difficult to say, however, if pain was a significant issue, I would start with levomilnacipran. However, if you were also going to use a TCA, you might get by with vilazodone + a noradrenergic TCA like desipramine.





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