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Re: Suggestions on treating Tardive Dyskinesia TD?

Posted by SLS on October 30, 2020, at 15:25:04

In reply to Suggestions on treating Tardive Dyskinesia TD?, posted by SLS on October 30, 2020, at 14:46:52

I forgot about these:

***** There are two new drugs approved specifically for treating TD *****

1. valbenazine (Ingrezza)
2. deutetrabenazine (Austedo)

Your doctor has hopefully discussed this with you. They are probably prohibitively expensive. I dont know. Below, I wrote a brief descripton of the mechanism of action.

Both of these drugs have the same novel mechanism of actions that doesnt involve dopamine receptors. TD presumably occurs because postsynaptic dopamine receptors become super-sensitive when they are blocked by an antipsychotics for too long. The mechanism of action of the new drugs involves preventing the presynaptic neuron from releasing too much dopamine into the synaptic cleft, which would otherwise overstimulate the postsynaptic receptors (the ones that became super-sensitive because of antipsychotic use). This is accomplished inside the presynaptic neuron by preventing dopamine from refilling the releasing vessicles. Technically, these drugs are both VMAT2 inhibitors.

In other words, the neuron cant spit because its mouth is dry.

If you dont get anything else out of this techinical crap, just remember the spitting.

- Scott

Some see things as they are and ask why.
I dream of things that never were and ask why not.

The only thing necessary for the triumph of evil is that good men do nothing.




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