Posted by SLS on August 15, 2020, at 18:21:28
In reply to Re: I can't take much more! Anxiety overwhelming!, posted by Englishman006! on August 11, 2020, at 22:32:36
> > I have found that there are unacceptable differences in the clinical effects of different brands of lamotrigine. Something should be done about it. To the best of my knowledge, no other anticonvulsant is so variable in its therapeutic effects. I have to jump through some hoops, but I use the Lamictal brand. Mylan lamotrigine was the worst. Teva lamotrigine was the best until they discontinued it and then resumed supplying it. All of their versions are now XR extended release. Obviously this isn't the same product they sold previously. My guess is that the drug is manufactured by the company they acquired, who was already making it. The first XR sold by Teva sucked, from what I understand. Still, it might be worth a try.
> >
> > If anyone feels that their generic lamotrigine works as well as the original Lamictal, please share your observations. Generic company and dosages would be great information.
> >
> >
> > - Scott
>
> I have been on different brands of Lamotrigine and you're right, there is an extreme difference. I too take Lamictal. I've also reacted badly to dexamphetamine when it was made into extended release, high dose, by a compounding pharmacy. I think new xr versions or brands of any med should be taken with caution...
>
> Lamotrigine also gives me bad melasma, a side effect not mentioned in any of the literature I've read. I think I may be the odd one out on that skin pigmentation disorder. There doesn't seem to be an alternative glutamate blocker in its class, so I'm stuck with it.I think you're right about glutamate inhibitors and depression. Valproate is pretty good at reducing glutamate activity through the inhibition of GABA transaminase, and possibly through the blocking of sodium channels upstream.
- Scott
Some see things as they are and ask why.
I dream of things that never were and ask why not.The only thing necessary for the triumph of evil is that good men do nothing.
poster:SLS
thread:1111554
URL: http://www.dr-bob.org/babble/20200711/msgs/1111694.html