Posted by undopaminergic on May 18, 2020, at 8:56:28
In reply to Re: question: why are MAOIs dangerous with stimulants » undopaminergic, posted by linkadge on May 18, 2020, at 8:12:03
> Parnate can have an amphetamine like effect in that it also releases dopamine to some extent.
>What about serotonin and noradrenaline? Someone said Parnate could trigger temperature spikes, which suggests serotonin excess.
> Nardil doesn't have this effect directly, although it does metabolize to PEA which is an endogenous amphetamine. Interestingly inhibiting MAO-B also slows the breakdown of PEA.
>Indeed, PEA may be the main substrate (more than dopamine) of MAO-B. Someone suggested it (MAO-B) could be called phenethylaminase.
> MAO-B inhibitors can have stimulant like effects in some individuals.
>Does that apply to rasagiline? Selegiline (l-deprenyl) has l-amphetamine metabolites.
> I would argue that MAOIs would give a 'boost' to most people, but that for 'normal' people it might produce some degree of agitation.
>Some people don't like the effects of cocaine, probably because they have a high endogenous dopaminergic tone. This would likely apply to MAOIs as well.
-undopaminergic
poster:undopaminergic
thread:1110215
URL: http://www.dr-bob.org/babble/20200511/msgs/1110228.html