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NARDIL SHORTAGE....The end of Nardil is near?

Posted by cranez on May 7, 2020, at 10:52:35

Guys, I am in Australia. We have had MASSIVE problems getting Nardil.

It has been very hard to acquire Nardil here in Australia (and New Zealand, the UK, and other countries). I am sure you are all aware of this. I had a very lengthy conversation with a pharmacist at Link (Nardil's former Australian sponsor/distributor). She essentially said the following which concerns all MAOI users worldwide.

Can anyone provide any feedback or advice?

Manufacturing sites are inspected regularly (by the FDA and other authorities). In order to synthesize Nardil and Parnate, certain specialized equipment is required. This equipment is very costly.

All manufacturing sites are required, after a certain length of time, to have their old equipment replaced by new equipment (similar to the way a Boeing 747 plane can only fly a certain mileage and then must be replaced, by the airline company, by a new Boeing 747 plane)

After a certain length of time, all manufacturing sites must be upgraded. This means buying all new equipment, and any novel specialized equipment.

MAOIs (as opposed to SSRI's) requires manufacturing sites to expend more money in purchasing the specialized equipment required for producing MAOIs.

This is the result:

All Manufacturing sites that currently produce MAOIs will be asked to upgrade at a certain point in time.

Given that, globally, so few patients take MAOIs, there is little incentive for manufacturing sites to pay for the highly expensive equipment required to produce MAOIs. It is by no means a lucrative decision for them.

Thus, Nardil and Parnate will, within a few years, be no longer produced unless more patients take these medications**. Nardil will go first, and then Parnate.**

How can MAOIs be used more?

MAOIs will have to have more indications for their use; that is, conditions which makes MAOI treatment advisable (for example, a recent study on Prostate cancer suggests Nardil can provide a therapeutic effect)

More doctors will have to be educated on them and prescribe them more for the conditions for which they are already indicated (it should be known that even university lecturers who teach medical students psychopharmacology, often do not teach about MAOIs now).

Doctors have to know more about the material contained in sites such as
, and be aware of the journal articles that demonstrate the efficacy and safety of MAOIs.

After 20 years of studying these medications, there is no doubt at all in my mind that MAOIs are the most efficacious antidepressants available and are extremely safe when administered correctly. In fact, apart from in actively suicidal patients, there is no real justification as to why they should only be relegated as the "last treatment option". SSRIs are not as "side-effect free" as some suggest, and I have read plenty of cases where people had more side-effects on an SSRI than an MAOI.




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