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Re: Why is no one on Ketamine?

Posted by undopaminergic on January 26, 2020, at 8:01:23

In reply to Why is no one on Ketamine?, posted by Stargazer2 on January 25, 2020, at 22:19:23

> I would have thought anyone with TRD would be getting IV Ketamine when they reached a point where their depression is so severe it becomes too risky to not go that route.
> Has anyone tried it with any degree of success?

No, but I've tried memantine which has the same mechanism of action. It worked great for depressive symptoms, but actually it was too good, because it resulted in a state comparable to mania. There was an elated mood, less need for sleep, impulsiveness, and loss of critical thinking leading to the formation of delusions.

Ketamine is fine for occasional use, but chronic exposure to it can harm the bladder, and at least in studies on rats, it can cause damage to the retrosplenial cortex, also known as "Olney's lesions".





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