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Re: Pindolol (a beta-blocker) can alleviate depression

Posted by Hugh on December 13, 2019, at 20:40:18

In reply to Re: Pindolol (a beta-blocker) can alleviate depression, posted by linkadge on December 12, 2019, at 15:10:28

The authors surmise that the delayed effect of SSRIs results from an initial decreased firing rate of 5-HT neurons, caused by excess serotonin stimulating their cell body autoreceptors which exert negative feedback control on the neurons' firing activity. By blocking these autoreceptors, pindolol should accelerate the antidepressant effect of SSRIs.

In the first study, seven of nine untreated patients who received paroxetine with pindolol experienced a 50% decrease in depressive symptoms after one week. In the second study, 10 of 19 drug-resistant patients had a 50% decrease in depressive symptoms after one week of pindolol in addition to paroxetine, fluoxetine, or moclobemide. Interestingly, patients treated with sertraline failed to respond to pindolol augmentation. In both studies, the therapeutic effect of pindolol was maintained for at least 28 days of treatment.

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