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Re: Lamictal, overlapping glutaminergic AED agents

Posted by porkpiehat on November 9, 2019, at 11:09:21

In reply to Re: Lamictal, overlapping glutaminergic AED agents, posted by linkadge on November 9, 2019, at 8:19:44

> In terms of increased obsessiveness, this may or may not be caused by the glutamate actions. Lamictal may be increasing dopamine (or something). Have you noticed the same thing with other anticonvulsants? (i.e. increased OCD)?
> Linkadge

The other anticonvulsants I've tried seem to do the opposite in terms of rumination (make it much better/go away) Strangely, the brand name lamictal sometime improves my mood and socialability but can bring me to the brink of feeling hypomanic in the way that the generics never did. The smallest amount of stimulants will make me very hedonistic and disinhibited, so I wonder if there is something to the dopamine theory?

I've only ever tried the other anticonvulsants with Lamictal already on board, so it's hard to tell whether the dopiness is coming from the gabapentin/trileptal/topomax or from combining them with Lamictal. In any case I'm taking smaller doses of both. I've found lithium, topomax, and depakote feel like they increase my depression and social anxiety/apathy.

Right now I'm taking small amounts of ritalin or modafinil to help with the dopiness I'm getting after lamictal and the anhedonia/demotivation I get from celexa being back in the mix.

I haven't taken any meds yet this morning and I feel light and open. That will change with lamictal. Then I'll take a stim to get me out of a slump and then I'll be racy and drinking lol.




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