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Re: safely decreasing kynurenicacid w/o cell toxicity?

Posted by linkadge on November 9, 2019, at 8:25:57

In reply to safely decreasing kynurenicacid w/o cell toxicity?, posted by cadburyhesychasm on November 6, 2019, at 1:45:51

YES. This is something that I have researched.

There is an enzyme called indoleamine 2,3-dioxygenase (IDO) which is responsible for tryptophan metabolism. If this enzyme's levels are high, more tryptophan is converted to kynurenic acid, which can contribute to psychiatric issues. By inhibiting IDO, more tryptophan gets converted to serotonin.

This enzyme may play a (large?) role in how serotonin levels drop in psychiatric disorders. Stress tends to activate IDO.

So the solution? (no expert here but...) there are substances which inhibit IDO activation. Some examples include ginger root, rosmarinc acid, and marijuanna (both CBD and THC inhibit IDO).

There are like others. If you google "inhibits 2,3-dioxygenase" you might get some leads. Inhibiting IDO may also have a positive impact on certain cancers.





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