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Re: Another dose increase, another improvement

Posted by rovers95 on August 2, 2019, at 4:43:24

In reply to Re: Can antidepressants work quickly? porkpiehat, posted by SLS on July 23, 2019, at 7:26:38

> > If I understand correctly, a lot of AD's can spike a neurotransmitter or block/agonize a receptor immediately...then the brain down or upregulates something else in the follow couple of weeks where the "true" AD effect supposedly lies.
> >
> > I would think there would be some diagnostic value in responding better to the initial action vs the later state. I know this happens to me a lot.
>
> All of your thoughts make sense, and I have tended to embrace them in the past. Now, I also look at the immediate effect of ketamine and the role that BDNF and inflammation might play in the latency of response to antidepressants. Somewhere, there must be a balance between the adages, "the more we learn, the more we realize how little we understand" and "keep it simple, stupid".
>
> I don't know nearly as much now as I did 20 years ago.
>
>
> - Scott

Now I've gone from 75mg to 100mg and my mood has improved almost immediately, but (and it's a big but) these improvements don't seem to last beyond a few days. I guess I've only been on it at a therapeutic dose (at least 75mg) for 11 days so will give it time and hope that the feeling lasts this time out.

 

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