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AXS-05: Dextromethorphan/Bupropion for Depression

Posted by PeterMartin on April 2, 2019, at 21:27:41

The FDA just fast-tracked "AXS-05": AXS-05 consists of dextromethorphan, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, and bupropion, a norepinephrine and dopamine reuptake inhibitor that serves to increase the bioavailability of dextromethorphan.

More info: https://www.empr.com/home/news/investigational-agent-for-major-depressive-disorder-gets-fdas-breakthrough-designation/

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I guess I was ahead of the curve on this one in being an abuser of cough syrup (just the pure dextromethorphan cough kind) in the late '00s. It definitely helped w/ depression and seemed to give me a nice sense of detachment in a way. Too much would make you trip of course but I found once I started taking lamictal (lamotrigine) that blunted most of the hallucinogenic effects and I could tolerate pretty high dosages w/ just a nice calm/AD effect.

Anyway I figured there'd be an anti-depressant w/ dextromethorphan coming since Nudexda (which is essentially dextromethorphan w/ the price inflated 200x) had done very well marketed for Alzheimers patients. I'm sure it'll be effective but probably costly which is sad cause the materials are dirt cheap (Re: robitussin is what $5 at walmart? and welbutrin is a cheap generic now).


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poster:PeterMartin thread:1103821
URL: http://www.dr-bob.org/babble/20190206/msgs/1103821.html