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Re: Moclobemide paradoxical reaction, or something Radish

Posted by SLS on February 24, 2019, at 14:18:28

In reply to Re: Moclobemide paradoxical reaction, or something, posted by Radish on February 24, 2019, at 7:15:26

> Thanks Scott... its strange.. any idea on how/why moc made us feel so awful?

I wish I could remember the specifics. It was a long time ago. If I remember correctly, I found an obscure abstract on Pubmed that led me to believe that moclobemide somehow reduced dopamine activation. It did not involve MAO inhibition. None of the other RIMAs had this property.

While searching for the old literature, this caught my eye.

"In humans, moclobemide increases plasma prolactin levels"

https://link.springer.com/article/10.2165/00003495-199243040-00009

Prolactin increase is often the result of decreased dopaminergic activity. Well, I snooped a little more and found that increased prolactin secretion is a consistent observation with moclobemide. Some investigators propose that this involves the stimulation of certain serotonin receptors. This might serve to decrease dopamine activity downstream, resulting in the increase of prolactin levels and the exacerbation of depression. Just a wild guess.

https://www.ncbi.nlm.nih.gov/pubmed/2250565


- Scott


Some see things as they are and ask why.
I dream of things that never were and ask why not.

- George Bernard Shaw

 

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